Hi,
Sorry for the issues you are having. I can help troubleshoot this with you.
It appears there is a bug that is preventing or not showing setting changes.
We are not sure of the cause, but downgrading to 4.1.3 will fix the issue.
You can download older versions of the core plugin here:
https://wordpress.org/plugins/the-events-calendar/developers/
And follow these steps to manually update the plugin:
Manual Updates
This process does not delete or change events or their settings.
Let us know if this helps the issue and we can go from there.
Thanks