Hi,
It is hard to say depends on what your experience is in and how many of the settings you would like to change.
The plugin sets up the main views (month, list, day, etc..) itself, so all you have to do is start adding in events, which is not much harder then creating a WordPress Post.
We have a new user primer that runs through the setup and settings:
New User Primer: The Events Calendar and Events Calendar Pro
And you can try out the plugin for free with the core version:
The Events Calendar
Let me know if you have any follow up questions.
Thanks