Yes: at a high level, you can use the tribe_events_single_event_meta filter which gives you access to the final chunk of HTML used to display the meta data – which you can then change at will.
Finely grained access to individual components is also possible via the tribe_get_meta filter (callbacks can optionally receive the meta ID to help identify which piece of meta data exactly they are looking at, in addition to the HTML segment) and similarly so for tribe_get_meta_group – which relates to a group of meta fields, such as the “Details” or “Venue” sections.
We also have some information about the meta walker, which puts this all together, over in our tutorials section:
Tribe Meta Walker: An Overview
Last but not least, if you really want to build a custom look and feel you could simply strip out the single-event.php template’s call to tribe_events_single_event_meta() and build things up exactly how you would like them to appear with your own code (which of course can leverage our own template tags).
I hope that gives you a few ideas!